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American Society of Microbiology ABMM Sample Questions:

1. A patient develops a severe, rapidly progressive pneumonia with hemoptysis. Gram stain of the sputum shows numerous small, pleomorphic Gram-negative coccobacilli. Growth on Bordet-Gengou agar is observed. The MOST likely causative agent is:

A) Moraxella catarrhalis
B) Bordetella pertussis
C) Legionella pneumophila
D) Haemophilus influenzae

2. A clinical microbiology laboratory is investigating a potential outbreak of Legionella pneumophila associated with a hospital's water system. The MOST appropriate environmental samples to collect for culture and comparison to clinical isolates would be:

A) Water samples from showers, faucets, and cooling towers.
B) Surface swabs from frequently touched objects.
C) Air samples from patient rooms and common areas.
D) Sputum samples from asymptomatic healthcare workers.

3. A patient returning from a hiking trip in a Lyme disease-endemic area presents with a unilateral facial nerve palsy, headache, and neck stiffness. Serological testing for Borrelia burgdorferi by ELISA is positive, but a Western blot shows only IgM bands. The MOST appropriate interpretation of these results is:

A) The patient has a false-positive ELISA result, and Lyme disease is unlikely.
B) The patient has early Lyme disease, and the IgM response is characteristic of recent infection.
C) The patient has chronic Lyme disease with a persistent IgM response.
D) The patient has a co-infection with another tick-borne pathogen causing a non-specific IgM response.

4. A patient with a history of exposure to bats in a cave develops progressive neurological symptoms, including hydrophobia. The MOST likely viral etiology is:

A) Rabies virus
B) West Nile virus
C) Japanese encephalitis virus
D) Herpes simplex virus encephalitis

5. A clinical microbiology laboratory is evaluating a new rapid diagnostic test for influenza viruses. The test has a high sensitivity but a lower specificity compared to RT-PCR. In a setting with a low prevalence of influenza, the use of this rapid test is MOST likely to result in a high number of:

A) False negative results
B) True positive results
C) False positive results
D) True negative results

Solutions: